The story of the series is about the Chuck Bartowski, who is working at a dead end job as a computer service expert at the Burbank with his best friend. Who are equally nerdy friends. Chuck is sharp minded but lacks ambition. But one day Chuck's life is suddeny turned, when his old friend and now Central Intelligence Agency (CIA) agent sends him a mysterious e-mail and the world's closely-kept spy secrets are embedded in Chuck's brain. Now Chuck has unwittingly become the government's most powerful weapon. Then the NSA's Major John Casey and CIA Agent Sarah Walker are dispatched to investigate.