This animated comedy series is telling us the story of employees of an international spy agency. Who work in the International Secret Intelligence Service (ISIS) at New York City. Their self centered master spy Sterling Archer deals with global espionage whose less-than-masculine code name is "Duchess". He works with his domineering mother Malory who is also Archer's boss. Archer also has to deal with his ex-girlfriend who is a part of ISIS and her new boyfriend who is ISIS accountant and his mother's lovesick secretary.